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EURenOMICS

EU grant of 12 M€ for new Kidney Consortium

EURenOMICS 21 Apr 2012

This newly awarded grant will bring together the leading clinical, genetic and translational researchers in the field of rare kidney diseases, who collectively have access to a unique array of well defined patient cohorts, biorepositories and state-of- the-art omics technologies and integrated systems biology platforms. From our university profs Bindels, Hoenderop and Wetzels participate in this new European consortium for high-throughput research in rare kidney diseases.

The fusion of existing patient registries in the EuRenOmics consortium will create the largest cohorts of high-level phenotypic and prospective clinical information and biomaterials ever collected in these rare disease entities. We will integrate comprehensive data sets from exome and whole-genome sequencing, genome-wide association studies, renal transcriptomic profiling, miRNomic and proteomic screens and immunological findings in different body fluids, renal metabolomic data and histomorphological aspects in individual patients and diseases, but also across conventional diagnostic categories. These data will be combined with high-resolution clinical phenotypes, molecular knowledge extracted from public domain data bases and the medical literature and findings obtained with a large array of established and innovative in vitro and in vivo models ('functionomics').

The kidney is a complex, highly regulated multicellular system that requires tightly controlled intrinsic and systemic regulation, which involves intracrine, autocrine, paracrine and humoral mechanisms. The application of omics technologies and systems biology approaches to disorders affecting individual components of this complex system will beparadigmatic in demonstrating the added value of integrated multi-scalar information processingin rare diseases. The understanding of the genetic and molecular causes of rare kidney diseases has advanced significantly in recent years. We have identified numerous abnormalities in genes involved in renal development, structure, and function. Some of these discoveries have opened new opportunities for targeted molecular therapies; however, the genetic and molecular basis of disease is still unknown in the majority of patients and will be investigated in this project.

Click here for press release in Dutch


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