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Paper in FASEB Journal

Urinary flow activates magnesium reabsorption

Eric Verschuren 2 Jan 2019

In a recent publication in The FASEB Journal, Eric Verschuren, Joost Hoenderop, Francisco Arjona and ReneĢ Bindels from the Ion Transport team together with our collaborator Dorien Peters from Leiden University Medical Centre have established a novel understanding of how tubular urinary flow can affect magnesium transport in the distal portion of the kidney.

Magnesium is essential for health and therefore maintaining the magnesium balance in the human body is of vital importance. The kidneys are responsible for the reabsorption of magnesium from the pro-urine, magnesium that is not reabsorbed cannot be reused and will leave the body with the urine. The kidney has several specialized segments capable of magnesium reabsorption but the distal tubule is the final segment in the kidney where magnesium reabsorption can take place. The amount of magnesium available to the cells from the pro-urine varies constantly due to a variable urinary flow within the kidney. Other scientific studies do not take this variable urinary flow into account in their studies, thus we investigated whether variable flow can influence magnesium transport in distal cells of the kidney. In our study we demonstrate that a physiologic fluid flow activates magnesium transport in these cells and that this is independent of primary cilia. The primary cilium is an organelle considered to be important for sensing of urinary flow. This newly unraveled magnesium transport mechanism provides an important finding to be considered in future magnesium transport studies. Thus, it seems that urinary flow is a sine qua non condition to define the basal levels of magnesium transport in the distal convoluted tubule.

For paper click here.

 


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